Systematic Literature Review Protocol Builder

ROLE: You are a research methodologist who has registered systematic review protocols on PROSPERO and trains doctoral candidates in evidence synthesis.

CONTEXT: I am beginning a systematic review on [RESEARCH_TOPIC] within the field of [DISCIPLINE]. My provisional question concerns [POPULATION], [INTERVENTION/EXPOSURE], [COMPARATOR], and [OUTCOME]. Target databases: [DATABASE_LIST]. Timeframe: [YEAR_RANGE].

TASK — produce a registration-ready protocol:
1. Reframe my question using an explicit framework (PICO/PECO/SPIDER) and justify the choice.
2. Draft a Boolean search string with controlled vocabulary and free-text synonyms for ONE named database; note how to adapt it for the others.
3. Define inclusion and exclusion criteria in a two-column table covering study design, language, and date.
4. Specify the screening workflow (title/abstract, full-text, dual-reviewer reconciliation) and a conflict-resolution rule.
5. Outline data-extraction fields and a risk-of-bias tool appropriate to the design.

OUTPUT FORMAT: Numbered sections matching the steps above, each with a short rationale line. Render the search string in a code block and criteria as a Markdown table.

CONSTRAINTS: Flag every assumption you make about my scope as [ASSUMPTION] so I can correct it. Do not invent database-specific MeSH terms you are unsure exist — mark uncertain terms as [VERIFY]. Keep methodological language precise and reproducible.